The electronic moisture-proof picture frame is different from the traditional picture frame. On the side of the picture frame, there is a humidity control module. Humidity control module includes dehumidification machine, door inside of the picture frame and door outside of the picture frame. At the beginning, the door outside the picture frame is closed, and the door inside the picture frame is opened. The dehumidifier can extract the water in the picture frame evenly at a very low speed. When the moisture content in the picture frame reaches the set value, the door inside the picture frame is closed, and the door outside the picture frame is opened. The humidity control module will heat the dehumidifier core, and the dehumidifier core will discharge the moisture, while the humidity inside the picture frame will not change because it is isolated from the outside.